I’m sorry to say that I just don’t know enough about this area of research to speculate on what they are doing about the issue you raise. I would assume they have done longitudinal studies, but again, I can’t say for sure, because we’re out of my wheelhouse when it come to this level of genetic work.

They have made diagnosis less subjective in research trials by giving research participants a standarized diagnostic interview. There are a few of them, the CIDI or the SCID, that are used for research purposes allowing for better validity.

Chances are I have a migraine. My spirit guides are Voltaire & Bierce. Considering making SJW into a religion. Genealogist

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